tapinarof   Click here for help

GtoPdb Ligand ID: 9686

Synonyms: GSK-2894512 | GSK2894512 [3] | Vtama® | WB-1001 | WBI 1001 | WBI-1001
Approved drug Immunopharmacology Ligand
tapinarof is an approved drug (FDA (2022))
Compound class: Synthetic organic
Comment: Tapinarof (GSK2894512) is an aryl hydrocarbon receptor (AhR) agonist [3]. It is a naturally occurring polyphenol derived from bacteria that exist symbiotically with entomopathogenic nematodes. AhR was identified as the primary molecular target based on phenotypic screening using the DiscoveRx BioMAP Diversity Plus System and confirmed using AhR knockout mice. Tapinarof was the first steroid-free topical drug in this class to be approved as a plaque psoriasis medication.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 40.46
Molecular weight 254.13
XLogP 5.04
No. Lipinski's rules broken 1
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Canonical SMILES CC(c1c(O)cc(cc1O)C=Cc1ccccc1)C
Isomeric SMILES CC(c1c(O)cc(cc1O)/C=C/c1ccccc1)C
InChI InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2022))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10253 tapinarof
Synonyms Click here for help
GSK-2894512 | GSK2894512 [3] | Vtama® | WB-1001 | WBI 1001 | WBI-1001
Database Links Click here for help
CAS Registry No. 79338-84-4 (source: WHO INN record)
ChEMBL Ligand CHEMBL259571
GtoPdb PubChem SID 348353645
PubChem CID 6439522
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UniChem Compound Search for chemical match using the InChIKey ZISJNXNHJRQYJO-CMDGGOBGSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZISJNXNHJRQYJO-CMDGGOBGSA-N