AMG3054

Comment: Apelin mimetic peptide agonist with reduced conformational flexibility, adopts a lactam constrained curved structure [1].

Peptide Sequence
KFRRQRPXXQHKKXXPX
Lys-Phe-Arg-Arg-Gln-Arg-Pro-hArg-Cha-Glu-His-Lys-Lys-Oic-Nle-Pro-4-Cl-Phe

Chemical Modification
hArg, Cha, Oic, Nle and 4-Cl-Phe are unnatural amino acid counterparts. There is a lactam ring between Glu⁸ and Lys¹³ [1].