- Guide to PHARMACOLOGY
Synonyms: morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl | morpholinurea-leucine-homophenylalaninevinyl phenyl sulfone
Compound class: Synthetic organic
Comment: LHVS is a small molecule, vinyl sulfone type, tool compound, which inhibits cathepsins L and S with low nanomolar potency .
Cathepsin S inhibitors are being investigated for clinical utility in inflammatory conditions. LHVS is reported to have neuroprotective action in models of traumatic brain injury .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl | morpholinurea-leucine-homophenylalaninevinyl phenyl sulfone|
|GtoPdb PubChem SID||318164817|
|Search Google for chemical match using the InChIKey||YUMYYTORLYHUFW-ZUDLOMHPSA-N|
|Search Google for chemicals with the same backbone||YUMYYTORLYHUFW|
|UniChem Compound Search for chemical match using the InChIKey||YUMYYTORLYHUFW-ZUDLOMHPSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||YUMYYTORLYHUFW-ZUDLOMHPSA-N|