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lutikizumab 
GtoPdb Ligand ID: 9297
|
Synonyms: ABT-981 | E26.13-SS-X3 [6]
Compound class:
Antibody
Comment: Lutikizumab (ABT-981) is an investigational monoclonal antibody targeting IL-1α and IL-1β [6], designed using proprietary technology to create dual variable domain antibodies ('DVD-IgTM') [3]. DVD-Igs are single pharmaceutical agents capable of simultaneously targeting two mediators of disease. The unique feature of DVD-Igs is that each arm of the antibody contains two tandem variable domains, each capable of binding a different antigen (see Figure 2 in [6]).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. |
| Immunopharmacology Comments |
| Lutikizumab (ABT-981) potently neutralizes biological activity of both IL-1α and IL-1β [6]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Osteoarthritis |
Disease Ontology:
DOID:8398 |
Phase 2 clinical candidate for OA. | |
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