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landogrozumab   Click here for help

GtoPdb Ligand ID: 8730

Synonyms: LY-2495655 | LY2495655
Compound class: Antibody
Comment: Landogrozumab is an investigational anti-myostatin, humanized, monoclonal antibody.
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record.
A BLAST protein search using the light and heavy chain variable regions of landogrozumab, identifies 100% matches with sequences patented in US7632499 B2 [2], and point towards clone 3-74/C1E4, as a preferred embodiment, taken forward for further anaylsis.
Bioactivity Comments
Affinity data in the table below is that provided in [2], for clone 3-74/C1E4.
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand
Sp.
Type
Action
Value
Parameter
Reference
myostatin {Sp: Human} Peptide Primary target of this compound Hs Antibody Binding 11.9 pKd - 2
⤷ pKd 11.9 (Kd 1.39x10-12 M) [2]
Description: Measured using the Sapidyne KINEXA assay.