MM07

Ligand id: 8523

Name: MM07

Structure and Physico-chemical Properties

2D Structure
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Classification
Compound class Peptide or derivative
IUPAC Name
L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine (1->6)-disulfide
Synonyms
cyclo[1-6]CRPRLCHKGPMPF
Comments
MM07, is a cyclic peptide agonist of the apelin receptor that is more stable than the endogenous apelin peptide. It acts as a biased agonist at the apelin receptor, that can preferentially stimulate the G protein pathway. It was hypothesised that this biased action could translate to improved efficacy in vitro by selectively stimulating vasodilatation and inotropic actions, whilst avoiding activation of detrimental β-arrestin-dependent pathways.

HELM annotation for MM07 is PEPTIDE1{C.R.P.R.L.C.H.K.G.P.M.P.F}$PEPTIDE1,PEPTIDE1,1:R3-6:R3$$$. We generated this and the SMILES for MM07 using HELM Editor v1.4 (from Pistoia Alliance). The IUPAC condensed nomenclature is H-Cys(1)-Arg-Pro-Arg-Leu-Cys(1)-His-Lys-Gly-Pro-Met-Pro-Phe-OH.
Database Links
GtoPdb PubChem SID 252166725
PubChem CID 134828250
Search Google for chemical match using the InChIKey RKFGCZWTURNFPN-SVENNQHVSA-N
Search Google for chemicals with the same backbone RKFGCZWTURNFPN
Search UniChem for chemical match using the InChIKey RKFGCZWTURNFPN-SVENNQHVSA-N
Search UniChem for chemicals with the same backbone RKFGCZWTURNFPN