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inotuzumab ozogamicin   Click here for help

GtoPdb Ligand ID: 8266

Synonyms: Besponsa® | CMC-544
Approved drug Immunopharmacology Ligand
inotuzumab ozogamicin is an approved drug (EMA & FDA (2017))
Compound class: Antibody
Comment: Inotuzumab ozogamicin is an antibody-drug conjugate (ADC) that targets delivery of the highly cytotoxic ozogamicin (a derivative of calicheamicin γ1) to CD22 (SIGLEC-2) +ve myeloid cells [1]. The calicheamicin derivative is N-acetyl gamma calicheamicin dimethylhydrazide as reported by DiJoseph et al (2004) [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes. EU EMA (2017)  |  US FDA (2017)
International Nonproprietary Names Click here for help
INN number INN
8574 inotuzumab ozogamicin
Synonyms Click here for help
Besponsa® | CMC-544
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 259
Other databases
GtoPdb PubChem SID 252166478
Search PubMed clinical trials inotuzumab ozogamicin
Search PubMed titles inotuzumab ozogamicin
Search PubMed titles/abstracts inotuzumab ozogamicin
Wikipedia Inotuzumab ozogamicin