CXCL1   Click here for help

GtoPdb Ligand ID: 819

Synonyms: GROα | melanocyte growth-stimulatory activity | MIP-2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL1 is a C-X-C motif chemokine expressed by macrophages, neutrophils and epithelial cells, that acts via the chemokine receptor CXCR2. CXCL1 is expressed by keratinocytes and endothelial cells at sites of epithelialization and neovascularization in the process of wound healing [2].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms Click here for help
GROα | melanocyte growth-stimulatory activity | MIP-2
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CXCL1 C-X-C motif chemokine ligand 1 Human chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), fibroblast secretory protein, FSP, GRO1, GRO1 oncogene (melanoma growth stimulating activity, alpha), GROa, MGSA, MGSA-a, NAP-3, SCYB1
Database Links Click here for help
Specialist databases
GPCRdb Ligand CXCL1
Other databases
Ensembl Gene ENSG00000163739 (Hs)
Entrez Gene 2919
GtoPdb PubChem SID 135651702
Human Protein Atlas ENSG00000163739 (Hs)
OMIM 155730
RefSeq Protein NP_001502
UniProtKB P09341 (Hs)
Wikipedia CXCL1