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levobetaxolol   Click here for help

GtoPdb Ligand ID: 8035

Synonyms: (-)-betaxolol | (S)-betaxolol | AL-1577A | Betaxon®
Approved drug
levobetaxolol is an approved drug (FDA (2000) no prior history available)
Compound class: Synthetic organic
Comment: This is the active isomer of betaxolol [1]. The clinically used compound is levobetaxolol hydrochloride (PubChem CID 60656).
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 50.72
Molecular weight 307.21
XLogP 2.37
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C
Isomeric SMILES O[C@H](COc1ccc(cc1)CCOCC1CC1)CNC(C)C
InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1
InChI Key NWIUTZDMDHAVTP-KRWDZBQOSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2000)
Withdrawn drug? Yes
IUPAC Name Click here for help
(2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol
International Nonproprietary Names Click here for help
INN number INN
6447 levobetaxolol
Synonyms Click here for help
(-)-betaxolol | (S)-betaxolol | AL-1577A | Betaxon®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9610984
Reactome Reaction Reactome logo R-HSA-9609310
Other databases
CAS Registry No. 93221-48-8
ChEBI CHEBI:59254
ChEMBL Ligand CHEMBL1201274
DrugCentral Ligand 4752
GtoPdb PubChem SID 249565715
PubChem CID 60657
Search Google for chemical match using the InChIKey NWIUTZDMDHAVTP-KRWDZBQOSA-N
Search Google for chemicals with the same backbone NWIUTZDMDHAVTP
Search PubMed clinical trials levobetaxolol
Search PubMed titles levobetaxolol
Search PubMed titles/abstracts levobetaxolol
UniChem Compound Search for chemical match using the InChIKey NWIUTZDMDHAVTP-KRWDZBQOSA-N
UniChem Connectivity Search for chemical match using the InChIKey NWIUTZDMDHAVTP-KRWDZBQOSA-N
Wikipedia Levobetaxolol