pomalidomide   Click here for help

GtoPdb Ligand ID: 7348

Synonyms: CC-4047 | IMID-3 | Imnovid® | Pomalyst®
Approved drug Immunopharmacology Ligand
pomalidomide is an approved drug (FDA and EMA (2013))
Compound class: Synthetic organic
Comment: Pomalidomide is an analogue of thalidomide with similar immunomodulatory antineoplastic activity.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 109.57
Molecular weight 273.07
XLogP -0.56
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C1CCC(C(=O)N1)N1C(=O)c2c(C1=O)c(N)ccc2
Isomeric SMILES O=C1CCC(C(=O)N1)N1C(=O)c2c(C1=O)c(N)ccc2
InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI Key UVSMNLNDYGZFPF-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
Approved drug? Yes (FDA and EMA (2013))
IUPAC Name Click here for help
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
International Nonproprietary Names Click here for help
INN number INN
8873 pomalidomide
Synonyms Click here for help
CC-4047 | IMID-3 | Imnovid® | Pomalyst®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9681202
Reactome Reaction Reactome logo R-HSA-9681169
Other databases
CAS Registry No. 19171-19-8 (source: Scifinder)
ChEMBL Ligand CHEMBL43452
DrugBank Ligand DB08910
DrugCentral Ligand 4746
GtoPdb PubChem SID 178103920
PubChem CID 134780
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Wikipedia Pomalidomide

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Tocris
Pomalidomide
Cat. No. 6302