carphenazine   Click here for help

GtoPdb Ligand ID: 7140

Synonyms: Proketazine® | WY-2445
Approved drug
carphenazine is an approved drug
Compound class: Synthetic organic
Comment: Carphenazine is an antipsychotic drug. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation. The Electronic Medicines Compendium (eMC) lists buclizine only as an active ingredient in a multi-component, anti-migraine treatment alongside paracetamol and codeine.
Marketed formulations may contain carphenazine maleate (PubChem CID 20838085).

carphenazine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 72.32
Molecular weight 425.21
XLogP 3.37
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(=O)CC
Isomeric SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(=O)CC
InChI InChI=1S/C24H31N3O2S/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28H,2,5,10-17H2,1H3
InChI Key XZSMZRXAEFNJCU-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes.
IUPAC Name Click here for help
1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)propan-1-one
International Nonproprietary Names Click here for help
INN number INN
1179 carfenazine
Synonyms Click here for help
Proketazine® | WY-2445
Database Links Click here for help
CAS Registry No. 2622-30-2
ChEMBL Ligand CHEMBL1201328
DrugBank Ligand DB01038
DrugCentral Ligand 516
GtoPdb PubChem SID 178103716
PubChem CID 18104
Search Google for chemical match using the InChIKey XZSMZRXAEFNJCU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XZSMZRXAEFNJCU
Search PubMed clinical trials carfenazine
Search PubMed titles carfenazine
Search PubMed titles/abstracts carfenazine
UniChem Compound Search for chemical match using the InChIKey XZSMZRXAEFNJCU-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey XZSMZRXAEFNJCU-UHFFFAOYSA-N
Wikipedia Carfenazine

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MedChemExpress
Carphenazine (links to external site)
Cat. No. HY-A0211