daclizumab   Click here for help

GtoPdb Ligand ID: 6880

Synonyms: L04AC01 | RO-24-7375 | Ro-247375 | Zenapax®
Approved drug Immunopharmacology Ligand
daclizumab is an approved drug (FDA FDA (1997), EMA (1999))
Compound class: Antibody
Comment: Daclizumab is a monoclonal antibody binding to the α subunit (CD25) of the high-affinity interleukin-2 receptor.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

An advanced version of daclizumab, with identical primary sequence, but which is differentially gylcosylated, called daclizumab beta (BIIB019, DAC HYP) has been developed for subcutaneous administration. Daclizumab beta's alternate glycosylation pattern changes its binding to Fc receptors and reduces its propensity to induce complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA FDA (1997), EMA (1999))
Withdrawn drug? Yes
International Nonproprietary Names Click here for help
INN number INN
7164 daclizumab
Synonyms Click here for help
L04AC01 | RO-24-7375 | Ro-247375 | Zenapax®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 36
Other databases
GtoPdb PubChem SID 178103462
PubChem SID 178103462
Search PubMed clinical trials daclizumab
Search PubMed titles daclizumab
Search PubMed titles/abstracts daclizumab
Wikipedia Daclizumab