etifoxine   Click here for help

GtoPdb Ligand ID: 5468

Synonyms: HOE 36-801 | HOE-36801
Compound class: Synthetic organic
Comment: Etifoxine is an racemic mixture of two enantiomers, which are represented on PubChem by CID 16742574 and CID 16742573. The structure shown here does not specify stereochemistry and represents the mixture.

Etifoxine's interaction with translocator protein (TSPO) has immunomodulatory action [1]. In microglia it directs expression of an immunosuppressive phenotype.

etifoxine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 33.62
Molecular weight 300.1
XLogP 5.12
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCN=C1Nc2ccc(cc2C(O1)(C)c1ccccc1)Cl
Isomeric SMILES CCN=C1Nc2ccc(cc2C(O1)(C)c1ccccc1)Cl
InChI InChI=1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)
InChI Key IBYCYJFUEJQSMK-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
6-chloro-N-ethyl-4-methyl-4-phenyl-2,4-dihydro-1H-3,1-benzoxazin-2-imine
International Nonproprietary Names Click here for help
INN number INN
2846 etifoxine
Synonyms Click here for help
HOE 36-801 | HOE-36801
Database Links Click here for help
CAS Registry No. 21715-46-8
ChEMBL Ligand CHEMBL2106227
DrugCentral Ligand 1099
GtoPdb PubChem SID 178102118
PubChem CID 135413553
Search Google for chemical match using the InChIKey IBYCYJFUEJQSMK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IBYCYJFUEJQSMK
Search PubMed clinical trials etifoxine
Search PubMed titles etifoxine
Search PubMed titles/abstracts etifoxine
UniChem Compound Search for chemical match using the InChIKey IBYCYJFUEJQSMK-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IBYCYJFUEJQSMK-UHFFFAOYSA-N
Wikipedia Etifoxine

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MedChemExpress
Etifoxine (links to external site)
Cat. No. HY-16579A