- Guide to PHARMACOLOGY
Synonyms: lithium ion
Li+ is an approved drug (FDA (1970))
Compound class: Inorganic
Comment: Lithium is a long-standing psychiatric medicine of unclear mechanism. A number of enzymes have been proposed as potential targets of lithium action, including inositol monophosphatase, a family of structurally related phosphomonoesterases, and the protein kinase glycogen synthase kinase-3 (see  and the DrugBank link). Administered as salt formulations such as the carbonate PubChem CID 11125
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: lithium
|Approved drug?||Yes (FDA (1970))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|CAS Registry No.||7439-93-2 (source: PubChem)|
|GtoPdb PubChem SID||178101897|