- Guide to PHARMACOLOGY
Synonyms: vascular endothelial growth factor A | vascular permeability factor (VPF) | VEGF-A
Compound class: Endogenous peptide in human, mouse or rat
Comment: The active peptide is anti-parallel homodimer linked by disulphide bonds. VEGFA exists as four isoforms of 121, 165, 189 and 206 amino acids. The shortest variant contains the full VEGFR2 binding site but lacks domains that are involved in interactions with extracellular-matrix and co-receptors which are present in the longer isoforms [14-15].
A recombinant single-chain derivative of VEGFA121 (scVEGF) can be used experimentally as a fully functional peptide that binds and activates VEGFR2 in the same manner as endogenous VEGFA . scVEGF can be labelled with a single fluorophore at its N-terminal, for use as a molecular probe .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Endogenous peptide in human, mouse or rat|
|Ligand families/groups||Vascular endothelial growth factor (VEGF) family ligands|
|vascular endothelial growth factor A | vascular permeability factor (VPF) | VEGF-A|
|DrugBank Target||P15692 (Hs)|
|Ensembl Gene||ENSG00000112715 (Hs)|
|GtoPdb PubChem SID||178101778|
|Human Protein Atlas||ENSG00000112715 (Hs)|