GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

tumour necrosis factor membrane form   Click here for help

GtoPdb Ligand ID: 5073

Abbreviated name: TNF membrane form
Synonyms: cachectin | necrosin | TNFα
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Tumor necrosis factor superfamily ligands
Synonyms Click here for help
cachectin | necrosin | TNFα
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNF tumor necrosis factor Human prepro-tumor necrosis factor DIF, TNFA, TNF-alpha, TNFSF2, TNF superfamily, member 2, tumor necrosis factor (TNF superfamily, member 2)
Database Links Click here for help
CATH/Gene3D 2.60.120.40
DrugBank Target P01375 (Hs)
Ensembl Gene ENSG00000204490 (Hs)
GtoPdb PubChem SID 178101766
Human Protein Atlas ENSG00000204490 (Hs)
UniProtKB P01375 (Hs)
Wikipedia Tumor_necrosis_factor-alpha