Synonyms: lipopolysaccharide derived from Gram-negative bacteria
Compound class:
Natural product
Comment: Lipopolysaccharides are complex molecules consisting of a core oligosaccharide, lipid A and O antigen (or O polysaccharide) joined by covalent bonds
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Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
TRPA1 | miRNA-711 is a selective activator of TRPA1 (pEC50 ~5.0) [2]. GRC 17536 (structure not disclosed) is a TRPA1 antagonist with potential as an anti-tussive therapeutic [4]. Some pathogen-derived molecules activate human TRPA1, such as lipopolysachharide (LPS) [3], indole (pEC50 4.1) [1] and indole-3-carboxyaldhyde (pEC50 4.1) [6]. |