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IL-12B   Click here for help

GtoPdb Ligand ID: 5002

Synonyms: IL-12 p40 | IL-12B monomer | interleukin-12β | interleukin-12B | natural killer cell stimulatory factor 2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: This is the common p40 subunit of pro-inflammatory cytokines IL-12 and IL-23.
Species: Human
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
ustekinumab Peptide Approved drug Primary target of this compound Hs Antibody Inhibition >9.0 – 11.1 pKd - 1
⤷ pKd >9.0 – 11.1 (Kd <1x10-9 – 7x10-12 M) [1]
briakinumab Peptide Primary target of this compound Hs Antibody Binding >10.0 pKd - 2
⤷ pKd >10.0 (Kd <1x10-10 M) [2]
ebdarokimab Peptide Approved drug Hs Antibody Binding - - -
⤷