IL-6   Click here for help

GtoPdb Ligand ID: 4998

Synonyms: B-cell stimulatory factor 2 | CTL differentiation factor | hybridoma growth factor | interferon β2 | interleukin-6
Immunopharmacology Ligand
Comment: IL-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. It is the originating member of a family of related cytokines that include IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1/B-cell stimulating factor 3 (NNT-1), neuropoietin (NPN), IL-27, and IL-31 [14]. IL-6 is produced by T and B cells, macrophages, dendritic cells, and non-immune cells such as fibroblasts, endothelial cells, glial cells, keratinocytes, and placental syncytio- and extravillous trophoblasts.
The receptors for these cytokines (except IL-31) share a common signal transducing subunit gp130 (IL6ST).
IL-6 is a critical regulator of the immune system and has been widely implicated in autoimmune disease, infection responses and in the regulation of metabolic, regenerative, and neural processes.
Species: Human
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Synonyms Click here for help
B-cell stimulatory factor 2 | CTL differentiation factor | hybridoma growth factor | interferon β2 | interleukin-6
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IL6 interleukin 6 Human prepro-interleukin 6 BSF2, HGF, HSF, IFNB2, IL-6, interleukin 6 (interferon, beta 2)
Database Links Click here for help
GtoPdb PubChem SID 178101695
Immunopaedia Search IL-6
UniProtKB P05231 (Hs)
Wikipedia Interleukin_6