IL-2   Click here for help

GtoPdb Ligand ID: 4985

Synonyms: aldesleukin | interleukin-2 | Proleukin®
Approved drug Immunopharmacology Ligand
IL-2 is an approved drug (FDA (1992))
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-2 and IL-15 are cytokines that share common biological effects, but also exhibit distinct, and sometimes competing, functions [6]. Recombinant IL-2 is used clinically with the generic name aldesleukin.
Abbas et al. (2018) have written a review of IL-2 biology and the progress that has been made in developing IL-2 therapeutics [1].
Species: Human
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Peptide Sequence Click here for help
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHL
RPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Post-translational Modification
O-linked glycosylation of threonine residue at position 3; disulphide bond between cysteine residues at positions 58 and 105