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IL-1β   Click here for help

GtoPdb Ligand ID: 4974

Synonyms: catabolin | interleukin-1 beta
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-1β is an IL-1 family cytokine produced from the IL1B gene. It is produced by activated macrophages as a proprotein which is cleaved by cytosolic caspase 1 to the mature, active molecule.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-1 receptor, type I
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-1 receptor, type I Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
gevokizumab Peptide Primary target of this compound Hs Antibody Binding 12.5 pKd - 3,6
⤷ pKd 12.5 (Kd 3x10-13 M) [3,6]
lutikizumab Peptide Monkey Antibody Binding 10.8 pKd - 4
⤷ pKd 10.8 (Kd 1.53x10-11 M) [4]
lutikizumab Peptide Primary target of this compound Hs Antibody Binding 10.7 pKd - 4
⤷ pKd 10.7 (Kd 2.1x10-11 M) [4]
canakinumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 10.5 pKd - 1
⤷ pKd 10.5 (Kd 3.5x10-11 M) [1]
lutikizumab Peptide Primary target of this compound Hs Antibody Binding 11.1 pEC50 - 4
⤷ pEC50 11.1 (EC50 7.5x10-12 M) [4]
rilonacept Peptide Approved drug Primary target of this compound Hs Fusion protein Binding - - - 2,7
⤷ [2,7]
Targets where the ligand is described in the comment field
Target Comment
Interleukin-1 receptor, type II Decoy receptor that binds IL-1α (IL1A, P01583), IL-1β (IL1B, P01584) and IL-1 receptor antagonist (IL1RN, P18510).
Ligand mentioned in the following text fields
NOD-like receptor family overview