aspirin   Click here for help

GtoPdb Ligand ID: 4139

Synonyms: Acetophen® | acetylsalicylic acid | Aspirin®
Approved drug PDB Ligand Immunopharmacology Ligand
aspirin is an approved drug (FDA (no history prior to 1965))
Compound class: Synthetic organic
Comment: Aspirin is the prototypical cyclooxygenase inhibitor and inhibits the biosynthesis of prostaglandins. Aspirin acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 63.6
Molecular weight 180.04
XLogP 1.42
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(=O)Oc1ccccc1C(=O)O
Isomeric SMILES CC(=O)Oc1ccccc1C(=O)O
InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChI Key BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (no history prior to 1965))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
2-acetyloxybenzoic acid
Synonyms Click here for help
Acetophen® | acetylsalicylic acid | Aspirin®
Database Links Click here for help
CAS Registry No. 50-78-2 (source: Scifinder)
ChEBI CHEBI:15365
ChEMBL Ligand CHEMBL25
DrugBank Ligand DB00945
DrugCentral Ligand 74
GtoPdb PubChem SID 178100961
Immunopaedia Search aspirin
PubChem CID 2244
RCSB PDB Ligand AIN
Search Google for chemical match using the InChIKey BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BSYNRYMUTXBXSQ
UniChem Compound Search for chemical match using the InChIKey BSYNRYMUTXBXSQ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Wikipedia Aspirin

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Tocris
Aspirin (links to external site)
Cat. No. 4092