muscarinic toxin 3   Click here for help

GtoPdb Ligand ID: 313

Synonyms: mamba toxin-3 | MT3
Compound class: Peptide
Comment: MT3 (M4-toxin), like MT7 (M1-toxin), is a toxin from the venom of the Eastern green mamba (Dendroaspis augusticeps) [1,3,5].
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Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target
Sp.
Type
Action
Value
Parameter
Reference
M2 receptor Hs Antagonist Antagonist >6.3 pA2 - 4
pA2 >6.3 [4]
M4 receptor Hs Allosteric modulator Negative 8.7 pKi - 3-4
pKi 8.7 [3-4]
M4 receptor Hs Antagonist Antagonist 8.5 pKi - 2
pKi 8.5 (Ki 3x10-9 M) [2]
α2A-adrenoceptor Hs Antagonist Antagonist 8.3 pKi - 2
pKi 8.3 (Ki 5x10-9 M) [2]
M1 receptor Hs Antagonist Antagonist 7.1 pKi - 3
pKi 7.1 [3]
M2 receptor Hs Antagonist Antagonist <6.0 pKi - 3
pKi <6.0 [3]
M3 receptor Hs Antagonist Antagonist <6.0 pKi - 3
pKi <6.0 [3]
M5 receptor Hs Antagonist Antagonist <6.0 pKi - 3
pKi <6.0 [3]