dihydrotestosterone   Click here for help

GtoPdb Ligand ID: 2856

Abbreviated name: DHT
Synonyms: 17β-hydroxy-5α-androstan-3-one | 5α-dihydrotestosterone | androstanolone | stanolone
PDB Ligand
Compound class: Metabolite or derivative
Comment: Dihydrotestosterone is an androgenic metabolite of testosterone, it is the primary contributing factor in male pattern baldness.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dihydrotestosterone

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 290.22
XLogP 4.5
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C1CCC2(C(C1)CCC1C2CCC2(C1CCC2O)C)C
Isomeric SMILES O=C1CC[C@]2([C@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C)C
InChI InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
InChI Key NVKAWKQGWWIWPM-ABEVXSGRSA-N
Classification Click here for help
Compound class Metabolite or derivative
IUPAC Name Click here for help
(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
International Nonproprietary Names Click here for help
INN number INN
238 androstanolone
Synonyms Click here for help
17β-hydroxy-5α-androstan-3-one | 5α-dihydrotestosterone | androstanolone | stanolone
Database Links Click here for help
BindingDB Ligand 18161
CAS Registry No. 521-18-6 (source: Scifinder)
ChEBI CHEBI:16330
ChEMBL Ligand CHEMBL27769
DrugBank Ligand DB02901
DrugCentral Ligand 3927
GtoPdb PubChem SID 135651474
PubChem CID 10635
RCSB PDB Ligand DHT
Search Google for chemical match using the InChIKey NVKAWKQGWWIWPM-ABEVXSGRSA-N
Search Google for chemicals with the same backbone NVKAWKQGWWIWPM
Search PubMed clinical trials androstanolone
Search PubMed titles androstanolone
Search PubMed titles/abstracts androstanolone
SynPHARM 6559 (in complex with Androgen receptor)
14316 (in complex with Androgen receptor)
UniChem Compound Search for chemical match using the InChIKey NVKAWKQGWWIWPM-ABEVXSGRSA-N
UniChem Connectivity Search for chemical match using the InChIKey NVKAWKQGWWIWPM-ABEVXSGRSA-N
Wikipedia Dihydrotestosterone