NO   Click here for help

GtoPdb Ligand ID: 2509

Synonyms: INOmax® | nitric oxide | nitrogen monoxide
Approved drug
NO is an approved drug (FDA (1999), EMA (2001))
Compound class: Inorganic
Comment: Nitric oxide is a free radical and an important cellular signaling molecule involved in many physiological and pathological processes. The drugs nitroglycerin and amyl nitrite are nitric oxide precursors.
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
Endothelial NOS
Inducible NOS
Neuronal NOS
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
K2P16.1 Hs Activator - - - - 4
⤷ [4]
K2P17.1 Hs Activator - - - - 2
⤷ [2]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Guanylyl cyclase, α1β1 Primary target of this compound Hs Activator Activation - - -
⤷
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Endogenous inhibitors at adenylyl cyclase 6 Gαi, Ca2+, PKA-evoked phosphorylation, PKC-evoked phosphorylation, NO 1,5,8-10
Endogenous inhibitors at adenylyl cyclase 5 Gαi, Ca2+, PKA-evoked phosphorylation, Gβγ, NO 3,5-7,9
Endogenous ligand(s) at Guanylyl cyclase, α2β1 NO
Endogenous ligand(s) at Guanylyl cyclase, α1β1 NO
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
cPTIO Small molecule or natural product N/A None Binding - - -
⤷
Ligand mentioned in the following text fields
Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase overview