- Guide to PHARMACOLOGY
Synonyms: CI-1003 | suramine
suramin is an approved drug
Compound class: Synthetic organic
Comment: Suramin is an antiparasitic drug. It is also used in research as a broad-spectrum P2 receptor antagonist [1,5] and as a ryanodine receptor agonist .
Evidence from studies in mice [7-9], and from an early phase clinical trial suggest antipurinergic therapy (using suramin or other antipurinergic compounds) as a potential lead in the search for pharmacotherapeutic intervention in children with autism spectrum disorder (see Phase 1/2 clinical trial NCT02508259).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|CI-1003 | suramine|
|CAS Registry No.||145-63-1|
|GtoPdb PubChem SID||135651219|
|RCSB PDB Ligand||SVR|
|Search Google for chemical match using the InChIKey||FIAFUQMPZJWCLV-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||FIAFUQMPZJWCLV|
|Search PubMed clinical trials||suramin sodium|
|Search PubMed titles||suramin sodium|
|Search PubMed titles/abstracts||suramin sodium|
|UniChem Compound Search for chemical match using the InChIKey||FIAFUQMPZJWCLV-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||FIAFUQMPZJWCLV-UHFFFAOYSA-N|