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IWY357   Click here for help

GtoPdb Ligand ID: 13524

Synonyms: IWY-357 | NVP-IWY357
Antimalarial Ligand
Compound class: Synthetic organic
Comment: IWY357 is an orally bioavailable compound with antimalarial activity [2]. It is one of the antimalarials in the Medicine's for Malaria Venture (MMV) pipeline (link here) and is intended as a treatment for uncomplicated malaria with potential for resistance management. The chemical structure for IWY357 was revealed in the "First Time Disclosures" session at the ACS (Fall) 2024 meeting in Denver and it is one of the structures claimed in patent WO2023180964A1 [1]. The mechanism of action of IWY357 is not fully resolved.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 91.87
Molecular weight 449.44
XLogP 1.96
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=C(C2=NC(=CN=C2)C(=O)NCC(C)(C)N)NC3=CC=C(C=C13)S(F)(F)(F)(F)F
Isomeric SMILES FS(F)(F)(F)(C1=CC=C2NC(C3=NC(C(NCC(C)(C)N)=O)=CN=C3)=C(C)C2=C1)F
InChI InChI=1S/C18H20F5N5OS/c1-10-12-6-11(30(19,20,21,22)23)4-5-13(12)28-16(10)14-7-25-8-15(27-14)17(29)26-9-18(2,3)24/h4-8,28H,9,24H2,1-3H3,(H,26,29)
InChI Key HPXREYVNZDJZJA-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Huang RY, Kirrane Jr TM, Marx V, Mata AC, Sarko CR, Taft BR, Yokokawa F. (2023)
Pyrazine amide derivatives.
Patent number: WO2023180964A1. Assignee: Novartis AG. Priority date: 22/03/2023. Publication date: 28/09/2023.
2. Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. (2023)
Antimalarial drug discovery: progress and approaches.
Nat Rev Drug Discov, 22 (10): 807-826. [PMID:37652975]