navlimetostat   Click here for help

GtoPdb Ligand ID: 12116

Synonyms: (M)-27 | (S)-MRTX-1719 | MRTX-1719 | MRTX1719
PDB Ligand
Compound class: Synthetic organic
Comment: MRTX1719 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) [2]. As a component of the methylosome, PRMT5's methylation activity is essential for mammalian cell survival. In certain cancers with defects in the methionine salvage pathway, inhibiting PRMT5 is lethal [1]. Thus, PRMT5 is an oncology drug target.
The chemical structure of MRTX1719 is identical to that for the INN navlimetostat (proposed list 132, Feb. 2025).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 122.61
Molecular weight 464.12
XLogP 3.81
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES N#Cc1c(OC2CC2)cc(c(c1c1n(C)ncc1c1ccc2c(c1)c(CN)n[nH]c2=O)F)Cl
Isomeric SMILES NCc1c2c(ccc(c3c(c4c(C#N)c(OC5CC5)cc(Cl)c4F)n(C)nc3)c2)c(=O)[nH]n1
InChI InChI=1S/C23H18ClFN6O2/c1-31-22(20-15(8-26)19(33-12-3-4-12)7-17(24)21(20)25)16(10-28-31)11-2-5-13-14(6-11)18(9-27)29-30-23(13)32/h2,5-7,10,12H,3-4,9,27H2,1H3,(H,30,32)
InChI Key BZKIOORWZAXIBA-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile
International Nonproprietary Names Click here for help
INN number INN
13484 navlimetostat
Synonyms Click here for help
(M)-27 | (S)-MRTX-1719 | MRTX-1719 | MRTX1719
Database Links Click here for help
CAS Registry No. 2630904-45-7 (source: WHO INN record)
ChEMBL Ligand CHEMBL5075255
GtoPdb PubChem SID 472319238
PubChem CID 156151242
RCSB PDB Ligand 85K
Search Google for chemical match using the InChIKey BZKIOORWZAXIBA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BZKIOORWZAXIBA
Search PubMed clinical trials navlimetostat
Search PubMed titles navlimetostat
Search PubMed titles/abstracts navlimetostat
UniChem Compound Search for chemical match using the InChIKey BZKIOORWZAXIBA-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey BZKIOORWZAXIBA-UHFFFAOYSA-N

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MedChemExpress
MRTX-1719 (links to external site)
Cat. No. HY-139611
(S)-MRTX-1719 (links to external site)
Cat. No. HY-139611B