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FGF-21   Click here for help

GtoPdb Ligand ID: 11721

Synonyms: fibroblast growth factor 21
Compound class: Endogenous peptide in human, mouse or rat
Comment: FGF21 is a mitogen that is involved in the migration and differentiation of cells that are of mesodermal or neuroectodermal origin, and in metabolic regulation [2]. Klotho beta (KLB) appears to be required for FGF21's metabolic activity [3]. The peptide sequence provided here includes the signal peptide (MDSDETGFEHSGLWVSVLAGLLLGACQA).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
FGF21 can signal through FGFR1-3 that are bound by βKlotho. This mechanism increases glucose uptake in adipocytes that express FGFR1 [3]. FGF21 is reported to actively participate in skin wound healing [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
fibroblast growth factor receptor 1 Ligand is endogenous in the given species Hs Agonist Agonist 8.4 pEC50 - 4
⤷ pEC50 8.4 (EC50 4.5x10-9 M) [4]
Description: Determined in rat L6 cells expressing human FGFR1c/β-Klotho, measuring downstream ERK phosphorylation