aldafermin   Click here for help

GtoPdb Ligand ID: 11546

Synonyms: M70 | NGM-282 | NGM282
Compound class: Peptide or derivative
Comment: Aldafermin (NGM282) is a recombinant, engineered analogue of FGF-19 (FGF19-mimetic) that was developed by NGM Biopharmaceuticals. Acting via the FGFR4-β-Klotho (KLB) receptor complex, aldafermin acts to suppress cholesterol 7α-hydroxylase (CYP7A1), the first and rate-limiting enzyme for bile acids biosynthesis.
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
10948 aldafermin
Synonyms Click here for help
M70 | NGM-282 | NGM282
Database Links Click here for help
GtoPdb PubChem SID 441604918
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