- Guide to PHARMACOLOGY
Synonyms: K-777 | K11777 | S-001 | SLV213
Compound class: Synthetic organic
Comment: K777 is a clinical stage irreversible cysteine protease inhibitor. It has reported activity at human cathepsin L and other CA clade cysteine proteases [2-5]. Original reports revealed anti-parasitic effects in vitro and in animal models [1-2,6].
SARS-CoV-2: Cathepsin L in human host cells is implicated in the processing (cleavage) of the viral spike protein of SARS coronaviruses, that is part of the viral entry process. K777 blocks SARS-CoV-2 infection in vitro.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|K-777 | K11777 | S-001 | SLV213|
|GtoPdb PubChem SID||441604887|
|RCSB PDB Ligand||0IW, D1R|
|Search Google for chemical match using the InChIKey||VZSXPUDQSLKVIR-JDXGNMNLSA-N|
|Search Google for chemicals with the same backbone||VZSXPUDQSLKVIR|
|UniChem Compound Search for chemical match using the InChIKey||VZSXPUDQSLKVIR-JDXGNMNLSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||VZSXPUDQSLKVIR-JDXGNMNLSA-N|