azelaprag

Ligand id: 10061

Name: azelaprag

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 141.87
Molecular weight 523.2
XLogP 3.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S,3R)-N-[4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-1,2,4-triazol-3-yl]-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide
International Nonproprietary Names
INN number INN
10870 azelaprag
Synonyms
AMG 986 | AMG-986 | AMG986 | example 263 [WO2016187308A1]
Comments
Azelaprag (AMG 986) is an apelin receptor agonist that is claimed in Amgen's patent WO2016187308A1 (as example 263) [1]. The chemical structure is identical to that submitted to the WHO for the INN azelaprag. Apelin receptor agonists are being pursued for their clinical inotropic potential in the treatment of heart failure.
Database Links
GtoPdb PubChem SID 375973249
PubChem CID 122702529
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