Synonyms: KX-02 | KX2 361 | KX2361
Compound class:
Synthetic organic
Comment: KX2-361 is a small molecule with a dual mode of action. It is a Src kinase inhibitor and an inhibitor of tubulin polymerization [1]. It is being investigated for antiproliferative potential. It is closely related to tirbanibulin, and like KX2-391 is a peptide substrate site binder rather than a competitive ATP binding site inhibitor. KX2-361 is orally bioavailable and shows a significant level of brain tissue exposure following oral administration.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
N-[(3-fluorophenyl)methyl]-2-[5-(4-morpholin-4-ylphenyl)pyridin-2-yl]acetamide |
Synonyms ![]() |
KX-02 | KX2 361 | KX2361 |
Database Links ![]() |
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CAS Registry No. | 897016-26-1 (source: PubChem) |
GtoPdb PubChem SID | 374883891 |
PubChem CID | 11545920 |
Search Google for chemical match using the InChIKey | CMKKPJNMYLOUCE-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | CMKKPJNMYLOUCE |
UniChem Compound Search for chemical match using the InChIKey | CMKKPJNMYLOUCE-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | CMKKPJNMYLOUCE-UHFFFAOYSA-N |
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KX2-361 (links to external site)
Cat. No. HY-111187 |