ChEMBL ligand: CHEMBL3707313 (Aklief, CD5789, CD-5789, Trifarotene)
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] There should be some charts here, you may need to enable JavaScript!
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL	Activation of RARalpha (unknown origin) expressed in human HeLa cells co-expressing ERE-beta-Glob-Luc-SV-Neo incubated for 18 hrs by luciferase reporter gene assay	B	6.3	pKd	500	nM	Kd	US-20080015246-A1. Novel ligands that modulate RAR receptors and pharmaceutical/cosmetic compositions comprised thereof (2008)
GtoPdb	In a reported assay measuring activation mediated by agonist binding to the RARα ligand-binding domain.	-	6.3	pEC50	500	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL	Activation of RARbeta (unknown origin) expressed in human HeLa cells co-expressing ERE-beta-Glob-Luc-SV-Neo incubated for 18 hrs by luciferase reporter gene assay	B	7.82	pKd	15	nM	Kd	US-20080015246-A1. Novel ligands that modulate RAR receptors and pharmaceutical/cosmetic compositions comprised thereof (2008)
GtoPdb	In a reported assay measuring activation mediated by agonist binding to the RARβ ligand-binding domain.	-	6.9	pEC50	125	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]
ChEMBL	Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs by luciferase reporter gene assay	B	6.9	pEC50	125	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL	Activation of RARgamma (unknown origin) expressed in human HeLa cells co-expressing ERE-beta-Glob-Luc-SV-Neo incubated for 18 hrs by luciferase reporter gene assay	B	8.7	pKd	2	nM	Kd	US-20080015246-A1. Novel ligands that modulate RAR receptors and pharmaceutical/cosmetic compositions comprised thereof (2008)
GtoPdb	Ligand-induced activation in a cellular reporter assay utlising the RARγ receptor ligand-binding domain.	-	8.11	pEC50	7.7	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]
ChEMBL	Agonist activity at GAL4 DNA-binding domain-tagged RARgamma (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs by luciferase reporter gene assay	B	8.11	pEC50	7.7	nM	EC50	Bioorg Med Chem Lett (2018) 28: 1736-1741 [PMID:29706423]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]