balamapimod [Ligand Id: 9925] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2104954 (Balamapimod, MKI-833) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| GtoPdb | Measuring c-Raf mediated activation of MEK and phosphorylation of MEK substrate. | - | 6.94 | pIC50 | 114 | nM | IC50 | US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009) |
| SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| GtoPdb | Measuring inhibition substrate phosphorylation by p60c-src tyrosine kinase in an ELISA, using an anti-phosphotyrosine detection antibody. | - | 6.55 | pIC50 | 281 | nM | IC50 | US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
