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ChEMBL ligand: CHEMBL2104954 (Balamapimod, MKI-833) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Raf-1 proto-oncogene, serine/threonine kinase in Human [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
GtoPdb | Measuring c-Raf mediated activation of MEK and phosphorylation of MEK substrate. | - | 6.94 | pIC50 | 114 | nM | IC50 | US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009) |
SRC proto-oncogene, non-receptor tyrosine kinase in Human [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
GtoPdb | Measuring inhibition substrate phosphorylation by p60c-src tyrosine kinase in an ELISA, using an anti-phosphotyrosine detection antibody. | - | 6.55 | pIC50 | 281 | nM | IC50 | US20090062281A1. 3-quinolinecarbonitrile protein kinase inhibitors (2009) |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]