GW406381 [Ligand Id: 9850] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL364804 (Gw406381, Gw 406381, Gw-406381)
  • COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
  • This target only has 0 pki data point
  • 0
1 CHEMBL364804_lig_chart_1 Cyclooxygenase-1 Human
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  • COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
  • This target only has 0 pki data point
  • 0
2 CHEMBL364804_lig_chart_2 Cyclooxygenase-2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb - - 4.07 pIC50 >84200 nM IC50 Bioorg Med Chem Lett (2004) 14: 5445-8 [PMID:15454242]
ChEMBL Inhibition of human cyclooxygenase-1 expressed in COS cells B 4.07 pIC50 >84200 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 5445-5448 [PMID:15454242]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 8.52 pIC50 3 nM IC50 Bioorg Med Chem Lett (2004) 14: 5445-8 [PMID:15454242]
ChEMBL Inhibition of human cyclooxygenase-2 expressed in COS cells B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 5445-5448 [PMID:15454242]
ChEMBL Inhibition of human COX-2 expressed in human COS cells using arachidonic acid as substrate B 8.52 pIC50 3 nM IC50 Eur J Med Chem (2019) 162: 1-17 [PMID:30396033]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]