LHVS [Ligand Id: 9298] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL222649 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of human cathepsin B | B | 5.35 | pIC50 | 4504 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of human recombinant cathepsin B after 10 mins | B | 5.87 | pIC50 | 1360 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| GtoPdb | - | - | 5.87 | pIC50 | 1360 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| ChEMBL | Inhibition of human cathepsin-B | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3140-3144 [PMID:23639544] |
| cathepsin B/Cathepsin B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5187] [GtoPdb: 2343] [UniProtKB: P10605] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin B | B | 5.89 | pIC50 | 1277 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin B/Cathepsin B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2602] [GtoPdb: 2343] [UniProtKB: P00787] | ||||||||
| ChEMBL | Inhibition of rat liver lysosomal cathepsin B | B | 6.13 | pIC50 | 735 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin G/Cathepsin G in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5622] [GtoPdb: 2348] [UniProtKB: P28293] | ||||||||
| ChEMBL | Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs | B | 4.4 | pIC50 | 39800 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| ChEMBL | Inhibition of human cathepsin K | B | 8.21 | pIC50 | 6.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of human cathepsin-K | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3140-3144 [PMID:23639544] |
| cathepsin K/Cathepsin K in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075277] [GtoPdb: 2350] [UniProtKB: P55097] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin K | B | 6.41 | pIC50 | 388 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| Cathepsin L in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295862] [UniProtKB: Q6DMN0] | ||||||||
| ChEMBL | Inhibition of Toxoplasma gondii cathepsin L using Z-L-R-AMC as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by spectrophotometric method | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1972-1980 [PMID:29650289] |
| cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| ChEMBL | Inhibition of human recombinant cathepsin L after 10 mins | B | 8.15 | pIC50 | 7 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| ChEMBL | Inhibition of human cathepsin L | B | 8.24 | pIC50 | 5.7 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of human cathepsin L using Z-L-R-AMC as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by spectrophotometric method | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1972-1980 [PMID:29650289] |
| cathepsin V/Cathepsin L in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2305] [GtoPdb: 2352] [UniProtKB: P07154] | ||||||||
| ChEMBL | Inhibition of rat liver lysosomal cathepsin L | B | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| cathepsin L/Cathepsin L1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5291] [GtoPdb: 2351] [UniProtKB: P06797] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin L | B | 8.15 | pIC50 | 7.1 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of human cathepsin-S | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3140-3144 [PMID:23639544] |
| ChEMBL | Inhibition of human cathepsin S | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| ChEMBL | Inhibition of human recombinant cathepsin S after 10 mins | B | 9 | pIC50 | 1 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| cathepsin S/Cathepsin S in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4098] [GtoPdb: 2353] [UniProtKB: O70370] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin S | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin S/Cathepsin S in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075217] [GtoPdb: 2353] [UniProtKB: Q02765] | ||||||||
| ChEMBL | Inhibition of rat spleen cathepsin S | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of human recombinant cathepsin C after 10 mins | B | 5 | pIC50 | >10000 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| proteinase 3/Myeloblastin in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5384] [GtoPdb: 2401] [UniProtKB: Q61096] | ||||||||
| ChEMBL | Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs | B | 4.67 | pIC50 | 21200 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| elastase, neutrophil expressed/Neutrophil elastase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5156] [GtoPdb: 2358] [UniProtKB: Q3UP87] | ||||||||
| ChEMBL | Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs | B | 4.59 | pIC50 | 25500 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
