SC-22716 [Ligand Id: 9102] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL119054 (SC-22716) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] | ||||||||
| ChEMBL | Inhibitory activity was determined for LTB4 production in human whole blood. | F | 6.1 | pIC50 | 790 | nM | IC50 | J Med Chem (2000) 43: 721-735 [PMID:10691697] |
| ChEMBL | Inhibition of human whole blood LTB-4 production (Leukotriene B-4). | F | 6.1 | pIC50 | 790 | nM | IC50 | J Med Chem (2002) 45: 3482-3490 [PMID:12139459] |
| ChEMBL | Inhibitory activity was determined against Leukotriene A4 hydrolase | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2000) 43: 721-735 [PMID:10691697] |
| ChEMBL | Inhibition of human leukotriene A4 hydrolase (LTA-4). | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2002) 45: 3482-3490 [PMID:12139459] |
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2000) 43: 721-35 [PMID:10691697] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
