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ChEMBL ligand: CHEMBL481422 (SM-122) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] | ||||||||
ChEMBL | Binding affinity to human cIAP1 BIR2-BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Binding affinity to human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay | B | 8.17 | pKi | 6.8 | nM | Ki | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 8.17 | pKi | 6.7 | nM | Ki | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay | B | 8.17 | pKi | 6.7 | nM | Ki | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | J Med Chem (2008) 51: 8158-62 [PMID:19049347] |
ChEMBL | Displacement of fluorescently tagged SM5F from human cIAP-1 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2008) 51: 8158-8162 [PMID:19049347] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2009) 52: 593-596 [PMID:19138149] |
ChEMBL | Competitive inhibition of human cIAP1BIR2-BIR3 domain after 2 to 3 hrs by fluorescence polarization assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 7.34 | pIC50 | 46.2 | nM | IC50 | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay | B | 7.34 | pIC50 | 46.2 | nM | IC50 | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Competitive inhibition of human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay | B | 7.42 | pIC50 | 38 | nM | IC50 | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] | ||||||||
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 7.74 | pKi | 18.3 | nM | Ki | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Binding affinity to BIR3 domain of cIAP2 by fluorescence polarization assay | B | 7.74 | pKi | 18.3 | nM | Ki | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Binding affinity to human cIAP2 BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 8.74 | pKi | 1.84 | nM | Ki | J Med Chem (2009) 52: 593-596 [PMID:19138149] |
GtoPdb | - | - | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (2008) 51: 8158-62 [PMID:19049347] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 7.13 | pIC50 | 74.7 | nM | IC50 | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Binding affinity to BIR3 domain of cIAP2 by fluorescence polarization assay | B | 7.13 | pIC50 | 74.7 | nM | IC50 | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Competitive inhibition of human cIAP2 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09] | ||||||||
ChEMBL | Displacement of fluorescently tagged SM5F from human cIAP-2 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (2008) 51: 8158-8162 [PMID:19049347] |
Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9] | ||||||||
ChEMBL | Inhibition of Zika virus NS2B-NS3 protease | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126965-126965 [PMID:31980339] |
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] | ||||||||
ChEMBL | Binding affinity to XIAP-BIR3 domain (unknown origin) | B | 7.59 | pKd | 26 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
ChEMBL | Binding affinity to BIR2 domain of XIAP by fluorescence polarization assay | B | 5.09 | pKi | 8200 | nM | Ki | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 6.39 | pKi | 408 | nM | Ki | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay | B | 6.39 | pKi | 408 | nM | Ki | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay | B | 6.61 | pKi | 248 | nM | Ki | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay | B | 6.72 | pKi | 191 | nM | Ki | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 6.72 | pKi | 190.7 | nM | Ki | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (2009) 52: 593-596 [PMID:19138149] |
ChEMBL | Binding affinity to N-terminal 6xHis-tagged human cloned XIAP BIR3 domain expressed in Escherichia coli BL21 (DE3) by fluorescence polarization-based competitive binding assay | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (2008) 51: 7169-7180 [PMID:18954041] |
GtoPdb | - | - | 7.59 | pKi | 26 | nM | Ki | J Med Chem (2008) 51: 8158-62 [PMID:19049347] |
ChEMBL | Binding affinity to BIR2 domain of XIAP by fluorescence polarization assay | B | 4.72 | pIC50 | 18900 | nM | IC50 | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Binding affinity to XIAP-BIR2 domain (unknown origin) | B | 5.25 | pIC50 | 5600 | nM | IC50 | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
ChEMBL | Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 5.91 | pIC50 | 1240 | nM | IC50 | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay | B | 5.91 | pIC50 | 1240 | nM | IC50 | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay | B | 6.09 | pIC50 | 819 | nM | IC50 | J Med Chem (2011) 54: 3306-3318 [PMID:21462933] |
ChEMBL | Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay | B | 6.2 | pIC50 | 636 | nM | IC50 | J Med Chem (2012) 55: 106-114 [PMID:22148838] |
ChEMBL | Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | B | 6.2 | pIC50 | 635.7 | nM | IC50 | J Med Chem (2010) 53: 6361-6367 [PMID:20684551] |
ChEMBL | Binding affinity to XIAP-BIR2/BIR3 domain (unknown origin) | B | 6.36 | pIC50 | 438 | nM | IC50 | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
ChEMBL | Inhibition of of XIAP-BIR2/BIR3 domain (unknown origin) | B | 6.36 | pIC50 | 438 | nM | IC50 | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
ChEMBL | Antagonist activity at human recombinant XIAP BIR3 protein assessed as restoration of caspase 9 activity after 60 mins | F | 6.2 | pEC50 | 630 | nM | EC50 | J Med Chem (2008) 51: 7169-7180 [PMID:18954041] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]