compound 35 [PMID: 23916259] [Ligand Id: 8842] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2420572 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Inhibition of human recombinant histidine-tagged full-length JNK1 expressed in insect cells using GST-tagged MAP2K7 as substrate after 1 hr by luminescence plate reader analysis | B | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-5222 [PMID:23916259] |
| GtoPdb | - | - | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-22 [PMID:23916259] |
| Microtubule associated serine/threonine kinase 3/Microtubule-associated serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417352] [GtoPdb: 1512] [UniProtKB: O60307] | ||||||||
| ChEMBL | Inhibition of MAST3 in human HuH7 cell lysates | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-5222 [PMID:23916259] |
| GtoPdb | - | - | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5217-22 [PMID:23916259] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
