compound 30 [PMID: 16455256] [Ligand Id: 8813] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL205742
  • Monocarboxylate transporter 1 in Human [ChEMBL: CHEMBL4360] [GtoPdb: 988] [UniProtKB: P53985]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monocarboxylate transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4360] [GtoPdb: 988] [UniProtKB: P53985]
ChEMBL Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione from MCT1 in human Jurkat cell membranes B 7.51 pKi 30.9 nM Ki Nat. Chem. Biol. (2005) 1: 371-376 [PMID:16370372]
ChEMBL Binding affinity to MCT1 by SPA B 8.32 pKi 4.8 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2260-2265 [PMID:16455256]
ChEMBL Binding affinity to MCT1 B 8.32 pKi 4.8 nM Ki J. Med. Chem. (2007) 50: 254-263 [PMID:17228867]
GtoPdb - - 8.32 pKi 4.8 nM Ki Bioorg Med Chem Lett (2006) 16: 2260-5 [PMID:16455256]
ChEMBL Displacement of [3H]5-[(3-hydroxypropyl)thio]-3-methyl-1-[2-(methyl-t)propyl-2,3-t2]-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione from human MCT1 expressed in INS1 cell membrane B 8.48 pKi 3.31 nM Ki Nat. Chem. Biol. (2005) 1: 371-376 [PMID:16370372]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]