ozanimod [Ligand Id: 8709] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| S1P1 receptor in Human [GtoPdb: 275] [UniProtKB: P21453] | ||||||||
| GtoPdb | In a GTPγS assay. | - | 9.39 | pEC50 | 0.41 | nM | EC50 | Br J Pharmacol (2016) 173: 1778-92 [PMID:26990079] |
| GtoPdb | - | - | 9.48 | pEC50 | 0.33 | nM | EC50 | PLoS One (2019) 14: e0226154 [PMID:31805144] |
| GtoPdb | In a cAMP assay. | - | 9.8 | pEC50 | 0.16 | nM | EC50 |
Mol Pharmacol (2008) 74: 1308-18 [PMID:18708635]; US20110172202 A1. Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis. (2011); Br J Pharmacol (2016) 173: 1778-92 [PMID:26990079] |
| S1P2 receptor in Human [GtoPdb: 276] [UniProtKB: O95136] | ||||||||
| GtoPdb | In a GTPγS assay. | - | 5 | pEC50 | >10000 | nM | EC50 | Br J Pharmacol (2016) 173: 1778-92 [PMID:26990079] |
| S1P3 receptor in Human [GtoPdb: 277] [UniProtKB: Q99500] | ||||||||
| GtoPdb | In a GTPγS assay. | - | 5 | pEC50 | >10000 | nM | EC50 | Br J Pharmacol (2016) 173: 1778-92 [PMID:26990079] |
| S1P4 receptor in Human [GtoPdb: 278] [UniProtKB: O95977] | ||||||||
| GtoPdb | In a β-arrestin assay. | - | 5.1 | pEC50 | >7865 | nM | EC50 | Br J Pharmacol (2016) 173: 1778-92 [PMID:26990079] |
| S1P5 receptor in Human [GtoPdb: 279] [UniProtKB: Q9H228] | ||||||||
| GtoPdb | - | - | 7.26 | pEC50 | 55.2 | nM | EC50 | US20110172202 A1. Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis. (2011) |
| GtoPdb | In a GTPγS assay. | - | 7.96 | pEC50 | 11 | nM | EC50 | Br J Pharmacol (2016) 173: 1778-92 [PMID:26990079] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
