compound 31 [PMID: 24809814] [Ligand Id: 8465] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3290331
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  • sphingosine-1-phosphate lyase 1/Sphingosine-1-phosphate lyase 1 in Human [ChEMBL: CHEMBL3286061] [GtoPdb: 2522] [UniProtKB: O95470]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
SMO/Smoothened homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835]
ChEMBL Antagonist activity at smoothened (unknown origin) B 6.36 pIC50 440 nM IC50 J Med Chem (2014) 57: 5074-5084 [PMID:24809814]
sphingosine-1-phosphate lyase 1/Sphingosine-1-phosphate lyase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286061] [GtoPdb: 2522] [UniProtKB: O95470]
ChEMBL Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hr B 6.68 pIC50 210 nM IC50 J Med Chem (2014) 57: 5074-5084 [PMID:24809814]
GtoPdb - - 6.68 pIC50 210 nM IC50 J Med Chem (2014) 57: 5074-84 [PMID:24809814];
Biochem Biophys Res Commun (2013) 433: 345-8 [PMID:23499842];
J Pharmacol Exp Ther (2016) 359: 151-8 [PMID:27519818];
Toxicol Pathol (2015) 43: 694-703 [PMID:25630683]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]