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ChEMBL ligand: CHEMBL2436980 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] | ||||||||
ChEMBL | Inhibition of human wild type LRRK2 by qPCR analysis | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2013) 56: 8032-48 [PMID:24044867] |
ChEMBL | Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATP | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434817] [GtoPdb: 2071] [UniProtKB: Q80XI6] | ||||||||
ChEMBL | Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISA | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]