Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL2062581 |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
ChEMBL | Inhibition of full length N-terminus His-tagged human CK2alpha expressed in insect Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 20 mins | B | 5.3 | pIC50 | 5000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464] |
ChEMBL | Inhibition of CK2alpha in human HCT116 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western blot analysis | B | 7.11 | pIC50 | 77 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 4.85 | pIC50 | 14000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
GtoPdb | - | - | 6.6 | pIC50 | 250 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464] |
ChEMBL | Inhibition of GSK3beta | B | 6.6 | pIC50 | 250 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464] |
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] | ||||||||
GtoPdb | - | - | 8.52 | pIC50 | <3 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464] |
ChEMBL | Inhibition of HipK2 | B | 8.52 | pIC50 | <3 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464] |
Casein kinase 2 in Human [GtoPdb: 1548] | ||||||||
GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464] |
dual specificity tyrosine phosphorylation regulated kinase 2 in Human [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]