compound 5b [PMID: 24900464] [Ligand Id: 8171] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2062581
  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
Created with Highcharts 10.3.3ValuesChart context menuCasein kinase II alphapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
Created with Highcharts 10.3.3ValuesChart context menuGlycogen synthase kinase-3 betapKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
Created with Highcharts 10.3.3ValuesChart context menuHomeodomain-interacting protein kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • Casein kinase 2 in Human [GtoPdb: 1548]
Created with Highcharts 10.3.3ValuesChart context menuCasein kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • dual specificity tyrosine phosphorylation regulated kinase 2 in Human [GtoPdb: 2011] [UniProtKB: Q92630]
Created with Highcharts 10.3.3ValuesChart context menudual specificity tyrosine phosphorylation regulated kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Inhibition of full length N-terminus His-tagged human CK2alpha expressed in insect Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 20 mins B 5.3 pIC50 5000 nM IC50 ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
ChEMBL Inhibition of CK2alpha in human HCT116 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western blot analysis B 7.11 pIC50 77 nM IC50 ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2 B 4.85 pIC50 14000 nM IC50 ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
GtoPdb - - 6.6 pIC50 250 nM IC50 ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]
ChEMBL Inhibition of GSK3beta B 6.6 pIC50 250 nM IC50 ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
GtoPdb - - 8.52 pIC50 <3 nM IC50 ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]
ChEMBL Inhibition of HipK2 B 8.52 pIC50 <3 nM IC50 ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
Casein kinase 2 in Human [GtoPdb: 1548]
GtoPdb - - 8.3 pIC50 5 nM IC50 ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]
dual specificity tyrosine phosphorylation regulated kinase 2 in Human [GtoPdb: 2011] [UniProtKB: Q92630]
GtoPdb - - 7.22 pIC50 60 nM IC50 ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]