ChEMBL ligand: CHEMBL2062581
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] There should be some charts here, you may need to enable JavaScript!
Casein kinase 2 in Human [GtoPdb: 1548] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 2 in Human [GtoPdb: 2011] [UniProtKB: Q92630] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL	Inhibition of full length N-terminus His-tagged human CK2alpha expressed in insect Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 20 mins	B	5.3	pIC50	5000	nM	IC50	ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
ChEMBL	Inhibition of CK2alpha in human HCT116 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western blot analysis	B	7.11	pIC50	77	nM	IC50	ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2	B	4.85	pIC50	14000	nM	IC50	ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
GtoPdb	-	-	6.6	pIC50	250	nM	IC50	ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]
ChEMBL	Inhibition of GSK3beta	B	6.6	pIC50	250	nM	IC50	ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
GtoPdb	-	-	8.52	pIC50	<3	nM	IC50	ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]
ChEMBL	Inhibition of HipK2	B	8.52	pIC50	<3	nM	IC50	ACS Med Chem Lett (2012) 3: 278-283 [PMID:24900464]
Casein kinase 2 in Human [GtoPdb: 1548]
GtoPdb	-	-	8.3	pIC50	5	nM	IC50	ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]
dual specificity tyrosine phosphorylation regulated kinase 2 in Human [GtoPdb: 2011] [UniProtKB: Q92630]
GtoPdb	-	-	7.22	pIC50	60	nM	IC50	ACS Med Chem Lett (2012) 3: 278-83 [PMID:24900464]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]