ChEMBL ligand: CHEMBL2392364
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL	Inhibition of CLK2 (unknown origin)	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb	-	-	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL	Inhibition of CLK3 (unknown origin)	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL	Inhibition of CLK4 (unknown origin) by bioluminescence assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
ChEMBL	Inhibition of CLK4 (unknown origin)	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb	-	-	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL	Inhibition of DYRK1A (unknown origin) by bioluminescence assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
ChEMBL	Inhibition of DYRK1A (unknown origin)	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb	-	-	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]
ChEMBL	Inhibition of DYRK1B (unknown origin)	B	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL	Inhibition of CLK1 (unknown origin)	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-3661 [PMID:23642479]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3654-61 [PMID:23642479]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]