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ChEMBL ligand: CHEMBL2037226 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5771] [GtoPdb: 1839] [UniProtKB: P97793] | ||||||||
ChEMBL | Inhibition of Tel-fused ALK in mouse BA/F3 cells | B | 5.47 | pIC50 | 3400 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
BMX non-receptor tyrosine kinase/Cytoplasmic tyrosine-protein kinase BMX in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034793] [GtoPdb: 1942] [UniProtKB: P97504] | ||||||||
ChEMBL | Inhibition of Tel-fused BMX in mouse BA/F3 cells | B | 5.17 | pIC50 | 6700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
EPH receptor A3/Ephrin type-A receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034794] [GtoPdb: 1823] [UniProtKB: P29319] | ||||||||
ChEMBL | Inhibition of Tel-fused EPHA3 in mouse BA/F3 cells | B | 5.23 | pIC50 | 5900 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
EPH receptor B2/Ephrin type-B receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5961] [GtoPdb: 1831] [UniProtKB: P54763] | ||||||||
ChEMBL | Inhibition of Tel-fused EPHB2 in mouse BA/F3 cells | B | 5.24 | pIC50 | 5800 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4066] [GtoPdb: 1810] [UniProtKB: Q61851] | ||||||||
ChEMBL | Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells | B | 5.03 | pIC50 | 9300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3839] [GtoPdb: 1811] [UniProtKB: Q03142] | ||||||||
ChEMBL | Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells | B | 5.15 | pIC50 | 7000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5585] [GtoPdb: 1815] [UniProtKB: P16056] | ||||||||
ChEMBL | Inhibition of Tel-fused MET in mouse BA/F3 cells | B | 5.24 | pIC50 | 5800 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5381] [GtoPdb: 1801] [UniProtKB: Q60751] | ||||||||
ChEMBL | Inhibition of Tel-fused IGF1R in mouse BA/F3 cells | B | 5.12 | pIC50 | 7600 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
Insulin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3187] [GtoPdb: 1800] [UniProtKB: P15208] | ||||||||
ChEMBL | Inhibition of Tel-fused INSR in mouse BA/F3 cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
colony stimulating factor 1 receptor/Macrophage colony-stimulating factor 1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5570] [GtoPdb: 1806] [UniProtKB: P09581] | ||||||||
ChEMBL | Inhibition of Tel-fused FMS in mouse BA/F3 cells | B | 5.4 | pIC50 | 4000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795170] [GtoPdb: 1816] [UniProtKB: Q62190] | ||||||||
ChEMBL | Inhibition of Tel-fused RON in mouse BA/F3 cells | B | 5.33 | pIC50 | 4700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034798] [GtoPdb: 1805] [UniProtKB: P05532] | ||||||||
ChEMBL | Inhibition of Tel-fused KIT in mouse BA/F3 cells | B | 6.04 | pIC50 | 910 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034797] [GtoPdb: 1497] [UniProtKB: Q9WTU6] | ||||||||
ChEMBL | Inhibition of Tel-fused JNK2 in mouse BA/F3 cells | B | 5.54 | pIC50 | 2900 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443] |
ChEMBL | Inhibition of TRKA by HTRF assay | B | 8.1 | pIC50 | 8 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
ChEMBL | Inhibition of TRKB by HTRF assay | B | 7.92 | pIC50 | 12 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
GtoPdb | - | - | 8.05 | pIC50 | 9 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443] |
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2749] [GtoPdb: 1804] [UniProtKB: P05622] | ||||||||
ChEMBL | Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells | B | 6.06 | pIC50 | 870 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
ret proto-oncogene/Proto-oncogene tyrosine-protein kinase receptor Ret in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034799] [GtoPdb: 2185] [UniProtKB: P35546] | ||||||||
ChEMBL | Inhibition of Tel-fused RET in mouse BA/F3 cells | B | 5.28 | pIC50 | 5300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034802] [GtoPdb: 1840] [UniProtKB: Q78DX7] | ||||||||
ChEMBL | Inhibition of Tel-fused ROS in mouse BA/F3 cells | B | 5.22 | pIC50 | 6000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342] | ||||||||
ChEMBL | Inhibition of Tel-fused FLT3 in mouse BA/F3 cells | B | 5.29 | pIC50 | 5100 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
ChEMBL | Inhibition of c-Kit in human Mo7e cells | B | 6 | pIC50 | 1000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fgr in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034795] [GtoPdb: 2024] [UniProtKB: P14234] | ||||||||
ChEMBL | Inhibition of Tel-fused FGR in mouse BA/F3 cells | B | 5.44 | pIC50 | 3600 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2258] [GtoPdb: 2060] [UniProtKB: P25911] | ||||||||
ChEMBL | Inhibition of Tel-fused LYN in mouse BA/F3 cells | B | 5.14 | pIC50 | 7300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034800] [GtoPdb: 1841] [UniProtKB: Q06806] | ||||||||
ChEMBL | Inhibition of Tel-fused TIE1 in mouse BA/F3 cells | B | 5.24 | pIC50 | 5700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480] | ||||||||
ChEMBL | Inhibition of Tel-fused SRC in mouse BA/F3 cells | B | 5.14 | pIC50 | 7300 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034801] [GtoPdb: 2285] [UniProtKB: P43404] | ||||||||
ChEMBL | Inhibition of Tel-fused ZAP70 in mouse BA/F3 cells | B | 5.33 | pIC50 | 4700 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969] | ||||||||
ChEMBL | Inhibition of Tel-fused FLT1 in mouse BA/F3 cells | B | 5.36 | pIC50 | 4400 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-145 [PMID:24900443] |
neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | ACS Med Chem Lett (2012) 3: 140-5 [PMID:24900443] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]