WH-4-023 [Ligand Id: 8068] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL213100
  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase p38 alphapKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase LCKpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase SRCpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of p38alpha B 5.89 pIC50 1300 nM IC50 J Med Chem (2006) 49: 4981-4991 [PMID:16884310]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Inhibition of Lck in presence of 0.5 uM ATP by HTRF kinase assay B 8.7 pIC50 2 nM IC50 J Med Chem (2006) 49: 4981-4991 [PMID:16884310]
GtoPdb - - 8.7 pIC50 2 nM IC50 J Med Chem (2006) 49: 4981-91 [PMID:16884310]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
GtoPdb - - 8.22 pIC50 6 nM IC50 J Med Chem (2006) 49: 4981-91 [PMID:16884310]
ChEMBL Inhibition of Src B 8.22 pIC50 6 nM IC50 J Med Chem (2006) 49: 4981-4991 [PMID:16884310]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of KDR B 6.19 pIC50 640 nM IC50 J Med Chem (2006) 49: 4981-4991 [PMID:16884310]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]