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ChEMBL ligand: CHEMBL213100 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Inhibition of p38alpha | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2006) 49: 4981-4991 [PMID:16884310] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of Lck in presence of 0.5 uM ATP by HTRF kinase assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2006) 49: 4981-4991 [PMID:16884310] |
GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2006) 49: 4981-91 [PMID:16884310] |
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
GtoPdb | - | - | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2006) 49: 4981-91 [PMID:16884310] |
ChEMBL | Inhibition of Src | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2006) 49: 4981-4991 [PMID:16884310] |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibition of KDR | B | 6.19 | pIC50 | 640 | nM | IC50 | J Med Chem (2006) 49: 4981-4991 [PMID:16884310] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]