ChEMBL ligand: CHEMBL3122117
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL	Inhibition of LRRK2 (unknown origin)	B	8.7	pKi	2	nM	Ki	J Med Chem (2014) 57: 921-936 [PMID:24354345]
ChEMBL	Affinity Biochemical interaction (Biochemical assay) EUB0000629a LRRK2	B	8.7	pKi	2	nM	Ki	Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3
GtoPdb	-	-	7.72	pIC50	19	nM	IC50	J Med Chem (2014) 57: 921-36 [PMID:24354345]
ChEMBL	Affinity On-target Cellular interaction (Cellular assay (LRRK2 phosphorylation)) EUB0000629a LRRK2	B	7.72	pIC50	19	nM	IC50	Affinity On-target Cellular Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL	Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assay	B	7.73	pIC50	18.7	nM	IC50	J Med Chem (2014) 57: 921-936 [PMID:24354345]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]