ML323 [Ligand Id: 7898] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3182437
  • ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782Q8TAF3]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782Q8TAF3]
ChEMBL Inhibition of USP1/UAF1 complex (unknown origin) by Ub-PCNA substrate assay B 6.09 pIC50 820 nM IC50 J. Med. Chem. (2015) 58: 1581-1595 [PMID:25364867]
ChEMBL Inhibition of USP1/UAF1 complex (unknown origin) assessed as reduction in K63-linked diUb cleavage by gel electrophoresis based orthogonal diUb cleavage assay B 6.76 pIC50 174 nM IC50 J. Med. Chem. (2015) 58: 1581-1595 [PMID:25364867]
ChEMBL Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assay B 7.12 pIC50 76 nM IC50 J. Med. Chem. (2014) 57: 8099-8110 [PMID:25229643]
ChEMBL Inhibition of USP1/UAF1 complex (unknown origin) by Ub-Rho110 assay B 7.12 pIC50 76 nM IC50 J. Med. Chem. (2015) 58: 1581-1595 [PMID:25364867]
GtoPdb - - 7.12 pIC50 76 nM IC50 J Med Chem (2014) 57: 8099-110 [PMID:25229643]
ChEMBL Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 days B 5.52 pEC50 3000 nM EC50 J. Med. Chem. (2014) 57: 8099-8110 [PMID:25229643]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]