ML323 [Ligand Id: 7898] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3182437 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3] | ||||||||
| ChEMBL | Inhibition of USP1/UAF1 complex (unknown origin) by Ub-PCNA substrate assay | B | 6.09 | pIC50 | 820 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
| ChEMBL | Inhibition of USP1/UAF1 complex (unknown origin) assessed as reduction in K63-linked diUb cleavage by gel electrophoresis based orthogonal diUb cleavage assay | B | 6.76 | pIC50 | 174 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
| ChEMBL | Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assay | B | 7.12 | pIC50 | 76 | nM | IC50 | J Med Chem (2014) 57: 8099-8110 [PMID:25229643] |
| ChEMBL | Inhibition of USP1/UAF1 complex (unknown origin) by Ub-Rho110 assay | B | 7.12 | pIC50 | 76 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
| GtoPdb | - | - | 7.12 | pIC50 | 76 | nM | IC50 | J Med Chem (2014) 57: 8099-110 [PMID:25229643] |
| ChEMBL | Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 days | B | 5.52 | pEC50 | 3000 | nM | EC50 | J Med Chem (2014) 57: 8099-8110 [PMID:25229643] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
