ML323 [Ligand Id: 7898] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3182437 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ubiquitin specific peptidase 1/Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430885] [GtoPdb: 2428] [UniProtKB: O94782, Q8TAF3] | ||||||||
| ChEMBL | Inhibition of USP1/UAF1 complex (unknown origin) by Ub-PCNA substrate assay | B | 6.09 | pIC50 | 820 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
| ChEMBL | Inhibition of USP1/UAF1 complex (unknown origin) assessed as reduction in K63-linked diUb cleavage by gel electrophoresis based orthogonal diUb cleavage assay | B | 6.76 | pIC50 | 174 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
| ChEMBL | Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assay | B | 7.12 | pIC50 | 76 | nM | IC50 | J Med Chem (2014) 57: 8099-8110 [PMID:25229643] |
| ChEMBL | Inhibition of USP1/UAF1 complex (unknown origin) by Ub-Rho110 assay | B | 7.12 | pIC50 | 76 | nM | IC50 | J Med Chem (2015) 58: 1581-1595 [PMID:25364867] |
| GtoPdb | - | - | 7.12 | pIC50 | 76 | nM | IC50 | J Med Chem (2014) 57: 8099-110 [PMID:25229643] |
| ChEMBL | Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 days | B | 5.52 | pEC50 | 3000 | nM | EC50 | J Med Chem (2014) 57: 8099-8110 [PMID:25229643] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
